sirtuin 2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9999	Sirtuin modulator 2	N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide	Others , Sirtuin
	Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.		Others , Sirtuin
T12919	SIRT-IN-2		Sirtuin
	SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).		Sirtuin
T6984	SirReal2		Sirtuin
	SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.		Sirtuin
T1887	Inauhzin	INZ	Sirtuin
	Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A54...		Sirtuin
T22026	AGK7		Others , Sirtuin
	AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively).		Others , Sirtuin
T4019	Cambinol	SIRT1/2 Inhibitor IV,NSC 112546	Apoptosis , Phospholipase , Sirtuin
	Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Ca...		Apoptosis , Phospholipase , Sirtuin
T6671	Sirtinol		Apoptosis , Sirtuin , Autophagy
	Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).		Apoptosis , Sirtuin , Autophagy
T6371	AGK2		Apoptosis , Sirtuin
	AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.		Apoptosis , Sirtuin
T1818	Tenovin-6	Tenovin 6	Dehydrogenase , Sirtuin , Autophagy
	Tenovin-6 is a p53 transcriptional activity agonist.		Dehydrogenase , Sirtuin , Autophagy
T1919	Tenovin-1	Tenovin 1	Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.		Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
T8480	Tenovin-6 Hydrochloride		Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
	Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .		Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
T22595	B2	Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline	Others , Sirtuin
	B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease		Others , Sirtuin
T5096	SRT 1720		Sirtuin , Autophagy
	SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.		Sirtuin , Autophagy
T2S0300	Dihydrocoumarin	Chroman-2-one,Hydrocoumarin,melilotin,2-chromanone,3,4-dihydrocoumarin	Sirtuin
	Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.		Sirtuin
T9320	YK-3-237	B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid	Sirtuin
	YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells ca...		Sirtuin
T8346	SRT 1460	SRT1460	Sirtuin
	SRT 1460 is a SIRT1 activator.		Sirtuin
T12920	Sirt2-IN-1		Sirtuin
	Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).		Sirtuin
T60064	WAY-270360	N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide	EGFR , Sirtuin
	WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.		EGFR , Sirtuin
T60001	Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)	3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide	Sirtuin
	Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for increasing the lifespan of a cell, and treating and/or pre...		Sirtuin
T5618	AK-1		Sirtuin
	AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.		Sirtuin